Semaglutide for Weight Loss: Men vs. Women

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that is FDA-approved for the treatment of obesity and type 2 diabetes. It works by increasing satiety and decreasing appetite, leading to weight loss.

A study published in the New England Journal of Medicine in 2020 found that semaglutide was effective for weight loss in both men and women. The study participants were randomly assigned to receive either semaglutide or a placebo for 68 weeks. The semaglutide group lost an average of 15.3% of their body weight, while the placebo group lost an average of 2.4%.

The study also found that semaglutide for weight loss was well-tolerated in both men and women. The most common side effects were nausea, vomiting, diarrhea, and constipation. These side effects were usually mild and resolved within a few weeks.

Overall, the study found that semaglutide is an effective and safe treatment for weight loss in both men and women.

Here are some additional details about the study:

  • The study included 1,961 participants who were overweight or obese.
  • The participants were randomly assigned to receive either semaglutide 0.25 mg, 0.5 mg, or 1.0 mg subcutaneously once weekly, or a placebo.
  • The primary outcome was change in body weight from baseline to week 68.
  • The secondary outcomes included changes in waist circumference, blood pressure, fasting blood glucose, and glycated hemoglobin A1c (HbA1c).
  • The study found that all doses of semaglutide were effective for weight loss. The semaglutide 1.0 mg group lost the most weight, an average of 15.3% of their  body weight.
  • The semaglutide 0.5 mg and 0.25 mg groups lost an average of 12.4% and 10.2% of their body weight, respectively.
  • The placebo group lost an average of 2.4% of their body weight.

The study also found that semaglutide was effective for improving other metabolic measures, such as waist circumference, blood pressure, fasting blood glucose, and HbA1c.

The study concluded that semaglutide is an effective and safe treatment for weight loss in both men and women.